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Article

Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.

Cell communication and signaling : CCS - 15 Aug 2013

Zuo Hao, Chan Grace P W, Zhu Jing, Yeung Wendy W S, Chan Anthony S L, Ammer Hermann, Wong Yung H

Abstract excerpt

BACKGROUND: The FHIT tumor suppressor gene is arguably the most commonly altered gene in cancer since it is inactivated in about 60% of human tumors. The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap3A. Despite the fact...

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Topics

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Share to Acid Anhydride Hydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Share to RNA, Small Interfering

Share to src-Family Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 23947369
DOI: 10.1186/1478-811X-11-59
PMCID: PMC3751744

Genes

DLD
FHIT
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23947369-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.PMID 23947369Read ↗

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