Article
Targeting inflammatory pathways in chronic lymphocytic leukemia.
Critical reviews in oncology/hematology - 1 Dec 2013
Rozovski Uri, Keating Michael J, Estrov Zeev
Abstract excerpt
Despite recent major advances in leukemia research, the pathobiology of chronic lymphocytic leukemia (CLL) remains poorly understood. Herein we review the role chronic inflammation plays in the initiation and progression of CLL. The robust production of inflammatory cytokines and chemokines accompanied by activation of intra-cellular pro-inflammatory pathways, and the presence of somatic mutations that activate...
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