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NF-κB as a therapeutic target in chronic lymphocytic leukemia

12 Feb 2010

Abstract excerpt

IMPORTANCE OF THE FIELD: NF-kappaB includes a family of transcription factors that play a critical role in the biology of normal lymphocytes and it is aberrantly activated in chronic lymphocytic leukemia (CLL) cells. Here, we review the role of constitutive NF-kappaB activation in CLL pathogenesis and its potential as a therapeutic target for CLL treatment. AREAS COVERED IN THIS REVIEW: This review highlights the...

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PMID: 20148715
DOI: 10.1517/14728221003598930

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