Article
NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions.
Seminars in cancer biology - 1 Aug 2016
Mansouri Larry, Papakonstantinou Nikos, Ntoufa Stavroula, Stamatopoulos Kostas, Rosenquist Richard
Abstract excerpt
The nuclear factor-κB (NF-κB) pathway is constitutively activated in chronic lymphocytic leukemia (CLL) patients, and hence plays a major role in disease development and evolution. In contrast to many other mature B-cell lymphomas, only a few recurrently mutated genes involved in canonical or non-canonical NF-κB activation have been identified in CLL (i.e. BIRC3, MYD88 and NFKBIE mutations) and often at a low...
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