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Article

Chronic lymphocytic leukemia: biology, disease progression, and current treatment strategies.

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2017

Yano Takahiro

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and accumulation of mature CD5-positive, CD10-negative, CD20 weakly positive, and CD23-positive B-cells within blood, bone marrow, lymph nodes, and spleen. In proliferation centers, the survival and growth of CLL cells requires a permissive microenvironment comprising T-cells, macrophages, and stromal cells. FISH analysis has revealed...

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Source

Identifiers

PMID: 28978838
DOI: 10.11406/rinketsu.58.1960

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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