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Article

[Pathogenesis of chronic lymphocytic leukemia].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Mar 2015

Fukuda Tetsuya

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a mature lymphoid malignancy that has a variable clinical course. Recent genomic studies using next-generation sequencers have revealed recurrent genetic alterations implicated in CLL pathogenesis. Clonal evolution by stepwise acquisition of genetic mutations may result in CLL progression. Among these abnormalities, alteration of B cell receptor (BCR) signaling is critical...

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Identifiers

PMID: 25876778
DOI: 10.11406/rinketsu.56.261

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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