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Article

Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures.

Molecular cell - 8 Aug 2013

Tham Khek-Chian, Hermans Nicolaas, Winterwerp Herrie H K, Cox Michael M, Wyman Claire, Kanaar Roland, Lebbink Joyce H G

Abstract excerpt

Homeologous recombination between divergent DNA sequences is inhibited by DNA mismatch repair. In Escherichia coli, MutS and MutL respond to DNA mismatches within recombination intermediates and prevent strand exchange via an unknown mechanism. Here, using purified proteins and DNA substrates, we find that in addition to mismatches within the heteroduplex region, secondary structures within the displaced...

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Identifiers

PMID: 23932715
DOI: 10.1016/j.molcel.2013.07.008
PMCID: PMC3781583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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