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Article

Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007

Pluciennik Anna, Modrich Paul

Abstract excerpt

The hemimethylated d(GATC) sequence that directs Escherichia coli mismatch repair can reside on either side of a mismatch at a separation distance of 1,000 bp or more. Initiation of repair involves the mismatch-, MutS-, and MutL-dependent activation of MutH endonuclease, which incises the unmethylated strand at the d(GATC) sequence, with the ensuing strand break serving as the loading site for the appropriate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17620611
DOI: 10.1073/pnas.0705129104
PMCID: PMC1913546

Genes

GATC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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