Article
Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors.
Scientific reports - 7 Jan 2016
Yelshanskaya Maria V, Saotome Kei, Singh Appu K, Sobolevsky Alexander I
Abstract excerpt
AMPA subtype ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission across excitatory synapses in the central nervous system. Each AMPA receptor is composed of four multi-domain subunits that are organized into layers of two amino-terminal domain (ATD) dimers, two ligand-binding domain (LBD) dimers, transmembrane domains and carboxy-terminal domains. We introduced cysteine...
Topics
- Amino Acid Substitution
- Cell Line
- Gene Knockout Techniques
- Humans
- Ion Channel Gating
- Models, Molecular
- Mutation
- Protein Conformation
- Protein Interaction Domains and Motifs
- Protein Multimerization
- Protein Subunits