Article
Clinical utility of immunohistochemistry for the detection of the BRAF v600e mutation in papillary thyroid carcinoma.
Surgery - 1 Dec 2013
Zagzag Jonathan, Pollack Aron, Dultz Linda, Dhar Shumon, Ogilvie Jennifer B, Heller Keith S, Deng Fang-Ming, Patel Kepal N
Abstract excerpt
BACKGROUND: BRAF V600E mutation is the most common genetic alteration in papillary thyroid cancer (PTC). We used a mutation-specific antibody for immunohistochemical (IHC) detection of the BRAF V600E mutation and correlated expression with clinicopathologic features. The study was designed to validate the accuracy and determine the clinical importance of IHC detection of the BRAF V600E mutation in PTC. METHODS:...
Topics
- Adult
- Antibody Specificity
- Carcinoma
- Carcinoma, Papillary
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutant Proteins
- Mutation
- Proto-Oncogene Proteins B-raf
- Reproducibility of Results
- Thyroid Cancer, Papillary