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Article

Utility of BRAF immunohistochemistry for the detection of BRAF mutations in papillary thyroid carcinoma. Analysis of detailed histological subtypes.

Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jan 2025

Uzun Evren, Erkilic Suna

Abstract excerpt

The BRAF mutation has been observed in 32-73% of papillary thyroid carcinomas. Despite the superiority of genetic tests for detecting BRAF mutations, they have inherent disadvantages. The objective of this study was to analyze the specificity and sensitivity of BRAF immunohistochemistry (IHC) that has been used in recent years and may serve as an alternative to genetic testing, in papillary thyroid carcinoma. A...

Topics

Humans
Proto-Oncogene Proteins B-raf
Thyroid Neoplasms
Immunohistochemistry
Thyroid Cancer, Papillary
Mutation
Biomarkers, Tumor
Female
Middle Aged
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Adult

Carcinoma, Papillary

Aged

Real-Time Polymerase Chain Reaction

Young Adult

Carcinoma

Sensitivity and Specificity

Source

Identifiers

PMID: 41910079
DOI: 10.5114/pjp.2025.158888

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41910079-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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