Article
Clinical significance of BRAF (V600E) mutation and Ki-67 labeling index in papillary thyroid carcinomas.
Anticancer research - 1 Jan 2000
Nakayama Hirotaka, Yoshida Akira, Nakamura Yoshiyasu, Hayashi Hiroyuki, Miyagi Youhei, Wada Nobuyuki, Rino Yasushi, Masuda Munetaka, Imada Toshio
Abstract excerpt
BACKGROUND: Activating mutations of the BRAF gene have recently been reported in thyroid carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma (PTC). PATIENTS AND METHODS: In this study, the BRAF (V600E) mutation in 54 PTCs was investigated and the relationship between the BRAF mutation and clinicopathological features such as age, gender, tumor size, extrathyroid extension,...
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