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Article

Genetic modification of corneal neovascularization in Dstn (corn1) mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2013

Kawakami-Schulz Sharolyn V, Sattler Shannon G, Doebley Anna-Lisa, Ikeda Akihiro, Ikeda Sakae

Abstract excerpt

Mutations in the gene for destrin (Dstn), an actin depolymerizing factor, lead to corneal abnormalities in mice. A null mutation in Dstn, termed Dstn (corn1) , isolated and maintained in the A.BY background (A.BY Dstn (corn1) ), results in corneal epithelial hyperproliferation, inflammation, and neovascularization. We previously reported that neovascularization in the cornea of Dstn (corn1) mice on the C57BL/6...

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Identifiers

PMID: 23929036
DOI: 10.1007/s00335-013-9468-9
PMCID: PMC3802551

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