Article
Spontaneous corneal hem- and lymphangiogenesis in mice with destrin-mutation depend on VEGFR3 signaling.
The American journal of pathology - 1 May 2005
Cursiefen Claus, Ikeda Sakae, Nishina Patsy M, Smith Richard S, Ikeda Akihiro, Jackson David, Mo Jun-Song, Chen Lu, Dana M Reza, Pytowski Bronislaw, Kruse Friedrich E, Streilein J Wayne
Abstract excerpt
Lymphangiogenesis, the formation of new lymphatic vessels, is important for tumor metastasis and induction of immunity to peripheral antigens including organ transplants. We herein describe a novel mouse model of spontaneous, secondary lymphangiogenesis in the normally avascular cornea. corn1 mice, which suffer from a deletion in the gene encoding the cytoskeletal protein destrin, develop hemangiogenesis as well...
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