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Article

A comparative analysis of C57BL/6J and 6N substrains; chemokine/cytokine expression and susceptibility to laser-induced choroidal neovascularization.

Experimental eye research - 1 Dec 2014

Schnabolk Gloriane, Stauffer Kimberly, O'Quinn Elizabeth, Coughlin Beth, Kunchithapautham Kannan, Rohrer Bärbel

Abstract excerpt

Age-related macular degeneration (AMD) is the most prevalent cause of blindness in the elderly. To study potential underlying mechanisms of AMD, animal models are utilized, focusing mostly on mice. Recently, genomic and phenotypic differences between the so-called control substrains, C57BL/6J and C57BL/6N, have been described in models of ocular and non-ocular diseases. In particular, the rd8 mutation of the Crb1...

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Identifiers

PMID: 25305577
DOI: 10.1016/j.exer.2014.10.005
PMCID: PMC5710800

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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