Article
Genetic loci that control the size of laser-induced choroidal neovascularization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2009
Nakai Kei, Rogers Michael S, Baba Takashi, Funakoshi Taisaku, Birsner Amy E, Luyindula Dema S, D'Amato Robert J
Abstract excerpt
Angiogenesis is controlled by a balance between stimulators and inhibitors. We propose that the balance, as well as the general sensitivity of the endothelium to these factors, varies from individual to individual. Indeed, we have found that individual mouse strains have dramatically different responses to growth factor-induced neovascularization. Quantitative trait loci (QTLs), which influence the extent of...
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