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Article

Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.

Physiological genomics - 15 Apr 2014

Kawakami-Schulz Sharolyn V, Verdoni Angela M, Sattler Shannon G, Jessen Erik, Kao Winston W-Y, Ikeda Akihiro, Ikeda Sakae

Abstract excerpt

Increased angiogenesis, inflammation, and proliferation are hallmarks of diseased tissues, and in vivo models of these disease phenotypes can provide insight into disease pathology. Dstn(corn1) mice, deficient for the actin depolymerizing factor destrin (DSTN), display an increase of serum response factor (SRF) that results in epithelial hyperproliferation, inflammation, and neovascularization in the cornea....

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Identifiers

PMID: 24550211
DOI: 10.1152/physiolgenomics.00126.2013
PMCID: PMC4035658

Genes

SRF
DSTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.PMID 24550211Read ↗

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