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Article

Defects in actin dynamics lead to an autoinflammatory condition through the upregulation of CXCL5.

PloS one - 16 Jul 2008

Verdoni Angela M, Smith Richard S, Ikeda Akihiro, Ikeda Sakae

Abstract excerpt

BACKGROUND: Destrin (DSTN) is a member of the ADF/cofilin family of proteins and is an important regulator of actin dynamics. The primary function of destrin is to depolymerize filamentous actin into its monomeric form and promote filament severing. While progress has been made in understanding t...

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Source

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Identifiers

PMID: 18628996
DOI: 10.1371/journal.pone.0002701
PMCID: PMC2442876

Genes

DSTN
CXCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18628996-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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