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Article

Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background.

Molecular vision - 1 Jan 2012

Kawakami-Schulz Sharolyn V, Verdoni Angela M, Sattler Shannon G, Ikeda Akihiro, Ikeda Sakae

Abstract excerpt

PURPOSE: Mutations in destrin (Dstn) cause corneal abnormalities in mice. A null mutation, Dstn(corn1), results in corneal epithelial hyperproliferation, inflammation, and neovascularization in the A.BY background (A.BY Dstn(corn1)). Homozygosity for a point mutation, Dstn(corn1-2J), results in mild thickening of the corneal epithelium but no corneal neovascularization in a C57BL/6 (B6) background (B6...

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PMID: 22419854
PMCID: PMC3298451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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