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Article

The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.

Development (Cambridge, England) - 1 Sept 2013

Lim Ai Khim, Lorthongpanich Chanchao, Chew Ting Gang, Tan Chin Wee Godwin, Shue Yan Ting, Balu Sathish, Gounko Natalia, Kuramochi-Miyagawa Satomi, Matzuk Martin M, Chuma Shinichiro, Messerschmidt Daniel M, Solter Davor, Knowles Barbara B

Abstract excerpt

Mobilization of endogenous retrotransposons can destabilize the genome, an imminent danger during epigenetic reprogramming of cells in the germline. The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway is known to silence retrotransposons in the mouse testes. Several piRNA pa...

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Topics

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Share to Gene Expression Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Infertility, Female

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Share to Ovarian Follicle

Share to Retroelements

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 23924633
DOI: 10.1242/dev.099184
PMCID: PMC4067262

Genes

PIWIL2
TDRD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23924633-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.PMID 23924633Read ↗

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

The tudor domain protein kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila.Semantic proximity Read ↗

Gender-Specific Hierarchy in Nuage Localization of PIWI-Interacting RNA Factors in DrosophilaSemantic proximity Read ↗

piRNA pathway is essential for generating functional oocytes in golden hamsterSemantic proximity Read ↗

Ovo is a master regulator of the piRNA pathway in animal ovarian germ cellsSemantic proximity Read ↗

Hen1 is required for oocyte development and piRNA stability in zebrafish.Semantic proximity Read ↗

PIWIL3-piRNA Pathway Is Essential for Rabbit Oogenesis and Embryogenesis via Broad Regulation of the Transcriptome and ProteomeSemantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary.Semantic proximity Read ↗

Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis.Semantic proximity Read ↗

Conserved enhancer association of piRNAs and the implication in germ cell fate surveillanceSemantic proximity Read ↗

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