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Article

The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.

Development (Cambridge, England) - 1 Sept 2013

Lim Ai Khim, Lorthongpanich Chanchao, Chew Ting Gang, Tan Chin Wee Godwin, Shue Yan Ting, Balu Sathish, Gounko Natalia, Kuramochi-Miyagawa Satomi, Matzuk Martin M, Chuma Shinichiro, Messerschmidt Daniel M, Solter Davor, Knowles Barbara B

Abstract excerpt

Mobilization of endogenous retrotransposons can destabilize the genome, an imminent danger during epigenetic reprogramming of cells in the germline. The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway is known to silence retrotransposons in the mouse testes. Several piRNA pathway components localize to the unique, germline structure known as the nuage. In this study, we surveyed mouse...

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Share to Gene Expression Regulation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germ Cells

Share to Infertility, Female

Share to Oogenesis

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Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 23924633
DOI: 10.1242/dev.099184
PMCID: PMC4067262

Genes

PIWIL2
TDRD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.PMID 23924633Read ↗

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

The tudor domain protein kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila.Semantic proximity Read ↗

Gender-Specific Hierarchy in Nuage Localization of PIWI-Interacting RNA Factors in DrosophilaSemantic proximity Read ↗

piRNA pathway is essential for generating functional oocytes in golden hamsterSemantic proximity Read ↗

Ovo is a master regulator of the piRNA pathway in animal ovarian germ cellsSemantic proximity Read ↗

Hen1 is required for oocyte development and piRNA stability in zebrafish.Semantic proximity Read ↗

PIWIL3-piRNA Pathway Is Essential for Rabbit Oogenesis and Embryogenesis via Broad Regulation of the Transcriptome and ProteomeSemantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary.Semantic proximity Read ↗

Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis.Semantic proximity Read ↗

Conserved enhancer association of piRNAs and the implication in germ cell fate surveillanceSemantic proximity Read ↗

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