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Article

Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis.

Developmental cell - 1 Aug 2008

Soper Sarah F C, van der Heijden Godfried W, Hardiman Tara C, Goodheart Mary, Martin Sandra L, de Boer Peter, Bortvin Alex

Abstract excerpt

Tight control of transposon activity is essential for the integrity of the germline. Recently, a germ-cell-specific organelle, nuage, was proposed to play a role in transposon repression. To test this hypothesis, we disrupted a murine homolog of a Drosophila nuage protein Maelstrom. Effects on ma...

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Source

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Identifiers

PMID: 18694567
DOI: 10.1016/j.devcel.2008.05.015
PMCID: PMC2546488

Genes

SPO11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18694567-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis.PMID 18694567Read ↗

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.Semantic proximity Read ↗

Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7.Semantic proximity Read ↗

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.Semantic proximity Read ↗

The tudor domain protein kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila.Semantic proximity Read ↗

Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.Semantic proximity Read ↗

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.Semantic proximity Read ↗

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.Semantic proximity Read ↗

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.Semantic proximity Read ↗

A kinesin Klp10A mediates cell cycle-dependent shuttling of Piwi between nucleus and nuageSemantic proximity Read ↗

AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline.Semantic proximity Read ↗

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