Article
Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.
The Biochemical journal - 15 Oct 2013
Fetterman Jessica L, Zelickson Blake R, Johnson Larry W, Moellering Douglas R, Westbrook David G, Pompilius Melissa, Sammy Melissa J, Johnson Michelle, Dunham-Snary Kimberly J, Cao Xuemei, Bradley Wayne E, Zhang Jinju, Wei Chih-Chang, Chacko Balu, Schurr Theodore G, Kesterson Robert A, Dell'italia Louis J, Darley-Usmar Victor M, Welch Danny R, Ballinger Scott W
Abstract excerpt
Dysfunctional bioenergetics has emerged as a key feature in many chronic pathologies such as diabetes and cardiovascular disease. This has led to the mitochondrial paradigm in which it has been proposed that mtDNA sequence variation contributes to disease susceptibility. In the present study we s...
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