Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling.

The Journal of biological chemistry - 22 Jun 2012

Sethumadhavan Savitha, Vasquez-Vivar Jeannette, Migrino Raymond Q, Harmann Leanne, Jacob Howard J, Lazar Jozef

Abstract excerpt

Myocardial remodeling and dysfunction are serious complications of type 2 diabetes mellitus (T2DM). Factors controlling their development are not well established. To specifically address the role of the mitochondrial genome, we developed novel conplastic rat strains, i.e. strains with the same nuclear genome but a different mitochondrial genome. The new animals were named T2DN(mtFHH) and T2DN(mtWistar), where...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Complications
Share to Echocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex I

Share to Electron Transport Complex IV

Share to Glucose Tolerance Test

Share to Heart Diseases

Share to Microscopy, Electron, Transmission

Share to Rats, Wistar

Source

Open in PubMed Open full text

Identifiers

PMID: 22544750
DOI: 10.1074/jbc.M111.327866
PMCID: PMC3381178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling.PMID 22544750Read ↗

Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.Semantic proximity Read ↗

Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction.Semantic proximity Read ↗

Initial Characterization of a Rat Model of Diabetic NephropathySemantic proximity Read ↗

Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria.Semantic proximity Read ↗

Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.Semantic proximity Read ↗

Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat.Semantic proximity Read ↗

Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome.Semantic proximity Read ↗

Mitochondrial polymorphisms in rat genetic models of hypertension.Semantic proximity Read ↗

A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation.Semantic proximity Read ↗

Complete mitochondrial genome sequence and mutations of the myocardial ischemia model inbred Sprague-Dawley strain.Semantic proximity Read ↗

Complete mitochondrial genome sequence and mutations of the cardiac hypertrophy model inbred rat strain (Muridae; Rattus).Semantic proximity Read ↗

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.