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Article

Genetic modifier of mitochondrial superoxide dismutase-deficient mice delays heart failure and prolongs survival.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2010

Kim Aekyong, Chen Chih-Hsin, Ursell Philip, Huang Ting-Ting

Abstract excerpt

Mn superoxide dismutase (MnSOD)-deficient mice (Sod2-/-) suffer from mitochondrial damage and have various survival times and phenotypic presentations that are dependent on the genetic background of the mutant mice. The mitochondrial NADPH transhydrogenase (NNT) was identified as a putative genetic modifier based on a genome-wide quantitative trait association study on the molecular defect of the protein in more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21069343
DOI: 10.1007/s00335-010-9299-x

Genes

NNT

Variants

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