Article
Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.
Physiological genomics - 1 May 2012
Houštek Josef, Hejzlarová Kateřina, Vrbacký Marek, Drahota Zdeněk, Landa Vladimír, Zídek Václav, Mlejnek Petr, Šimáková Miroslava, Šilhavy Jan, Mikšík Ivan, Kazdová Ludmila, Oliyarnyk Olena, Kurtz Theodore, Pravenec Michal
Abstract excerpt
Common inbred strains of the laboratory rat can be divided into four different mitochondrial DNA haplotype groups represented by the SHR, BN, LEW, and F344 strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. LEW mitochondrial genomes by comparing the SHR to a new SHR conplastic strain, SHR-mt(LEW); these strains are genetically identical except for their...
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