Article
Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction.
Physiological genomics - 15 Sept 2014
Houštěk Josef, Vrbacký Marek, Hejzlarová Kateřina, Zídek Václav, Landa Vladimír, Šilhavý Jan, Šimáková Miroslava, Mlejnek Petr, Kazdová Ludmila, Mikšík Ivan, Neckář Jan, Papoušek František, Kolář František, Kurtz Theodore W, Pravenec Michal
Abstract excerpt
Common inbred strains of the laboratory rat can be divided into four major mitochondrial DNA (mtDNA) haplotype groups represented by the BN, F344, LEW, and SHR strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. F344 mtDNA by comparing the SHR vs. SHR-mt(F344) conplastic strains that are genetically identical except for their mitochondrial genomes. Altogether 13...
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