Article
Archaea box C/D enzymes methylate two distinct substrate rRNA sequences with different efficiency.
RNA (New York, N.Y.) - 1 May 2016
Graziadei Andrea, Masiewicz Pawel, Lapinaite Audrone, Carlomagno Teresa
Abstract excerpt
RNA modifications confer complexity to the 4-nucleotide polymer; nevertheless, their exact function is mostly unknown. rRNA 2'-O-ribose methylation concentrates to ribosome functional sites and is important for ribosome biogenesis. The methyl group is transferred to rRNA by the box C/D RNPs: The rRNA sequence to be methylated is recognized by a complementary sequence on the guide RNA, which is part of the enzyme....
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