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Article

Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P.

Journal of molecular biology - 12 Aug 2011

Chen Wen-Yi, Xu Yiren, Cho I-Ming, Oruganti Sri Vidya, Foster Mark P, Gopalan Venkat

Abstract excerpt

Ribonuclease P (RNase P) is a ribonucleoprotein complex that utilizes a Mg(2+)-dependent RNA catalyst to cleave the 5' leader of precursor tRNAs (pre-tRNAs) and generate mature tRNAs. The bacterial RNase P protein (RPP) aids RNase P RNA (RPR) catalysis by promoting substrate binding, Mg(2+) coordination and product release. Archaeal RNase P comprises an RPR and at least four RPPs, which have eukaryal homologs and...

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Source

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Identifiers

PMID: 21683084
DOI: 10.1016/j.jmb.2011.05.012
PMCID: PMC3143260

Genes

RPP21
POP5
RPP30

Provenance

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