Article
HIV type 1 polymerase gene polymorphisms are associated with phenotypic differences in replication capacity and disease progression.
The Journal of infectious diseases - 1 Jan 2014
Ng Oon Tek, Laeyendecker Oliver, Redd Andrew D, Munshaw Supriya, Grabowski Mary K, Paquet Agnes C, Evans Mark C, Haddad Mojgan, Huang Wei, Robb Merlin L, Reynolds Steven J, Gray Ronald H, Wawer Maria J, Serwadda David, Eshleman Susan H, Quinn Thomas C
Abstract excerpt
BACKGROUND: Determinants of intersubtype differences in human immunodeficiency virus type 1 (HIV-1) clinical disease progression remain unknown. METHODS: HIV-1 subtype was independently determined for 5 separate genomic regions in 396 HIV-1 seroconverters from Rakai, Uganda, using a multiregion hybridization assay. Replication capacities (RC) in samples from a subset of 145 of these subjects were determined....
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