Article
Genotypic variation in the pol gene of HIV type 1 in an antiretroviral treatment-naive population in rural southwestern Uganda.
AIDS research and human retroviruses - 1 Oct 2006
Gale Catherine V, Yirrell David L, Campbell Eileen, Van der Paal Lieve, Grosskurth Heiner, Kaleebu Pontiano
Abstract excerpt
The majority of studies of HIV-1 drug resistance have involved subtype B viruses. Here we have characterized subtype distribution and determined the levels of polymorphism at protease (PR) and reverse transcriptase (RT) drug resistance positions, in antiretroviral treatment-naive HIV-positive Ugandan patients. We have also investigated codon usage variability at these positions and assessed intersubtype...
Topics
- Amino Acid Substitution
- Anti-HIV Agents
- Codon
- Cohort Studies
- Genes, pol
- Genetic Variation
- HIV Infections
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1
- Humans