Article
Association of HIV-1 replication capacity with treatment outcomes in patients with virologic treatment failure.
Journal of acquired immune deficiency syndromes (1999) - 1 Aug 2007
De Luca Andrea, Weidler Jodi, Di Giambenedetto Simona, Coakley Eoin, Cingolani Antonella, Bates Michael, Lie Yolanda, Pesano Rick, Cauda Roberto, Schapiro Jonathan
Abstract excerpt
BACKGROUND: The extent to which HIV-1 replication capacity (RC) influences the response to therapy remains to be established. METHODS: Phenotypic susceptibility and RC of baseline isolates (n = 139) from patients enrolled in the ARGENTA trial were measured and correlated to treatment outcomes over 36 months. RESULTS: RC in baseline isolates correlated with the number of phenotypically active drugs (R = 0.34, P <...
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