Article
HIV subtypes induce distinct profiles of HIV-specific CD8(+) T cell responses.
AIDS research and human retroviruses - 1 Feb 2008
Baker Chris A R, McEvers Kimberly, Byaruhanga Rose, Mulindwa Rwabaingi, Atwine Diana, Nantiba Josephine, Jones Norman G, Ssewanyana Isaac, Cao Huyen
Abstract excerpt
CD8(+) T cells play an important role in controlling HIV infection and qualitative differences in HIV-specific CD8(+) responses may determine the degree of immune control. We studied 56 HIV-infected, ARV-naive Ugandans and examined the role of subtypes in modulating their HIV-specific T cell responses. Gag-specific responses were readily detectable in our study population. Interestingly, we found significantly...
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