Article
Non-R5-tropic HIV-1 in subtype A1 and D infections were associated with lower pretherapy CD4+ cell count but not with PI/(N)NRTI therapy outcomes in Mbarara, Uganda.
AIDS (London, England) - 17 Jul 2016
Lee Guinevere Q, Lachowski Chris, Cai Eric, Lima Viviane D, Boum Yap, Muzoora Conrad, Mocello Adrienne Rain, Hunt Peter W, Martin Jeffrey N, Bangsberg David R, Harrigan P Richard
Abstract excerpt
BACKGROUND: Previous studies suggest that infection with non-R5-tropic subtype B HIV-1, compared with R5, is associated with a more rapid decline in CD4 cell count, but does not affect PI/(N)NRTI therapy outcome. Here, we explored clinical correlates associated with viral tropism in subtype A1 and D infections. METHODS: HIV-1 subtype A1 (n = 196) and D (n = 143) pretherapy plasma samples and up to 7.5 years of...
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