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Article

Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression.

Journal of virology - 1 Jul 2017

Kiguoya Marion W, Mann Jaclyn K, Chopera Denis, Gounder Kamini, Lee Guinevere Q, Hunt Peter W, Martin Jeffrey N, Ball T Blake, Kimani Joshua, Brumme Zabrina L, Brockman Mark A, Ndung'u Thumbi

Abstract excerpt

There are marked differences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progression have been reported. However, the biological reasons underlying these differences are unknown. Gag-protease is essential for HIV-1 replication, and Gag-protease-driven replication capacity has previously been correlated with disease progression. We show that Gag-protease replication...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28424286
DOI: 10.1128/JVI.00253-17
PMCID: PMC5469260

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