Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.

doi:10.1016/j.jpsychires.2013.07.004

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Article

Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.

Journal of psychiatric research - 1 Nov 2013

Zarchi Omer, Carmel Miri, Avni Chen, Attias Josef, Frisch Amos, Michaelovsky Elena, Patya Miriam, Green Tamar, Weinberger Ronnie, Weizman Abraham, Gothelf Doron

Abstract excerpt

22q11.2 deletion syndrome (22q11.2DS) is a common genetic risk factor for the development of schizophrenia. We investigated two neurophysiological endophenotypes of schizophrenia - P50 sensory gating and mismatch negativity in 22q11.2DS subject and evaluated their association with catechol O-methyltransferase (COMT) and proline dehydrogenase (PRODH) genetic variants. We also assessed the association of...

Topics

22q11 Deletion Syndrome
Acoustic Stimulation
Adolescent
Adult
Catechol O-Methyltransferase
Child
Contingent Negative Variation
Endophenotypes
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Polymorphism, Single Nucleotide

Proline Oxidase

Schizophrenia

Sensory Gating

Source

Open in PubMed

Identifiers

PMID: 23910792
DOI: 10.1016/j.jpsychires.2013.07.004

Genes

COMT
PRODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.