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Article

Dopamine dysfunction in 22q11 deletion syndrome: possible cause of motor symptoms.

Psychiatric genetics - 1 Oct 2016

Casarelli Livia, Minnei Maurizio, Pitzianti Mariabernarda, Armando Marco, Pontillo Maria, Vicari Stefano, Pasini Augusto

Abstract excerpt

22q11 Deletion syndrome (22q11DS) is a neurogenetic disorder, resulting from a hemizygous microdeletion on the long arm of chromosome 22. In 22q11DS, the phenotypic expression is highly variable. Approximately one-third of all individuals with 22q11DS develop schizophrenia-like psychotic disorder. Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric...

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Identifiers

PMID: 27548835
DOI: 10.1097/YPG.0000000000000144

Genes

COMT

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