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Article

COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.

Biological psychiatry - 1 Jul 2005

Baker Kate, Baldeweg Torsten, Sivagnanasundaram Sinthuja, Scambler Peter, Skuse David

Abstract excerpt

BACKGROUND: Microdeletions at 22q11.2 greatly increase the risk of schizophrenia in early adulthood (relative risk approximately 25-30). We hypothesized that before the onset of schizophrenia, individuals with 22q11DS would manifest specific cognitive and neurophysiological anomalies (endophenoty...

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Source

Identifiers

PMID: 15935994
DOI: 10.1016/j.biopsych.2005.03.020

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15935994-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.PMID 15935994Read ↗

Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.Semantic proximity Read ↗

Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Neuroimaging correlates of 22q11.2 deletion syndrome: implications for schizophrenia research.Semantic proximity Read ↗

No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.Semantic proximity Read ↗

Startle reactivity and prepulse inhibition of the acoustic startle response are modulated by catechol-O-methyl-transferase Val(158) Met polymorphism in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.Semantic proximity Read ↗

22q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basisSemantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Abnormal cortical activation during response inhibition in 22q11.2 deletion syndromeSemantic proximity Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.Semantic proximity Read ↗

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