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Article

COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.

Biological psychiatry - 1 Jul 2005

Baker Kate, Baldeweg Torsten, Sivagnanasundaram Sinthuja, Scambler Peter, Skuse David

Abstract excerpt

BACKGROUND: Microdeletions at 22q11.2 greatly increase the risk of schizophrenia in early adulthood (relative risk approximately 25-30). We hypothesized that before the onset of schizophrenia, individuals with 22q11DS would manifest specific cognitive and neurophysiological anomalies (endophenotypes) in common with individuals at high risk for schizophrenia in the general population. We further predicted that the...

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Source

Identifiers

PMID: 15935994
DOI: 10.1016/j.biopsych.2005.03.020

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.PMID 15935994Read ↗

Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.Semantic proximity Read ↗

Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Neuroimaging correlates of 22q11.2 deletion syndrome: implications for schizophrenia research.Semantic proximity Read ↗

No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.Semantic proximity Read ↗

Startle reactivity and prepulse inhibition of the acoustic startle response are modulated by catechol-O-methyl-transferase Val(158) Met polymorphism in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.Semantic proximity Read ↗

22q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basisSemantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Abnormal cortical activation during response inhibition in 22q11.2 deletion syndromeSemantic proximity Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.Semantic proximity Read ↗

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