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Article

Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.

The Journal of biological chemistry - 20 Sept 2013

Onono Fredrick, Subramanian Thangaiah, Sunkara Manjula, Subramanian Karunai Leela, Spielmann H Peter, Morris Andrew J

Abstract excerpt

Mammalian cells can use exogenous isoprenols to generate isoprenoid diphosphate substrates for protein isoprenylation, but the mechanism, efficiency, and biological importance of this process are not known. We developed mass spectrometry-based methods using chemical probes and newly synthesized s...

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Identifiers

PMID: 23908355
DOI: 10.1074/jbc.M113.482307
PMCID: PMC3779739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23908355-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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