Article
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.
Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2010
Liu Meng, Sjogren Anna-Karin M, Karlsson Christin, Ibrahim Mohamed X, Andersson Karin M E, Olofsson Frida J, Wahlstrom Annika M, Dalin Martin, Yu Huiming, Chen Zhenggang, Yang Shao H, Young Stephen G, Bergo Martin O
Abstract excerpt
RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase-I (GGTase-I). Inhibitors of FTase and GGTase-I were developed to block RAS-induced mal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.