Article
In Vivo Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome.
ACS chemical biology - 15 Aug 2025
Petre Alexandru M, Thieschafer Josslen S, Palsuledesai Charuta, Cornille Katie, Chang Allison, Li Ling, Distefano Mark D
Abstract excerpt
Prenylation is a ubiquitous process in eukaryotes consisting of the irreversible post-translational modification of proteins through the attachment of a lipophilic isoprenoid moiety to a cysteine residue near their C-terminus. Due to the important functional roles of prenylated proteins, their participation and/or dysregulation has been linked to numerous diseases, including ALS, progeria, cancer, and Alzheimer's...
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