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Article

Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

The Journal of biological chemistry - 12 Nov 2010

Berg Tracy J, Gastonguay Adam J, Lorimer Ellen L, Kuhnmuench John R, Li Rongshan, Fields Alan P, Williams Carol L

Abstract excerpt

Ras and Rho small GTPases possessing a C-terminal polybasic region (PBR) are vital signaling proteins whose misregulation can lead to cancer. Signaling by these proteins depends on their ability to bind guanine nucleotides and their prenylation with a geranylgeranyl or farnesyl isoprenoid moiety and subsequent trafficking to cellular membranes. There is little previous evidence that cellular signals can restrain...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20709748
DOI: 10.1074/jbc.M110.129916
PMCID: PMC2975149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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