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Article

Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.

Lipids in health and disease - 20 Dec 2017

Gbelcová Helena, Rimpelová Silvie, Knejzlík Zdeněk, Šáchová Jana, Kolář Michal, Strnad Hynek, Repiská Vanda, D'Acunto Walter Cosimo, Ruml Tomáš, Vítek Libor

Abstract excerpt

BACKGROUND: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in pancreatic cancer. In our study, we evaluated the effect of three key intermediates of the mevalonate pathway on...

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Identifiers

PMID: 29262834
DOI: 10.1186/s12944-017-0641-0
PMCID: PMC5738693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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