Article
A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes.
The Journal of biological chemistry - 29 Oct 1999
Gardner R G, Hampton R Y
Abstract excerpt
Sterol synthesis by the mevalonate pathway is modulated, in part, through feedback-regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). In both mammals and yeast, a non-sterol isoprenoid signal positively regulates the rate of HMGR degradation. To define more precisely the molecule that serves as the source of this signal, we have conducted both pharmacological and genetic...
Topics
- Alkyl and Aryl Transferases
- Alleles
- Bridged Bicyclo Compounds, Heterocyclic
- Enzyme Stability
- Eukaryotic Cells
- Farnesyl-Diphosphate Farnesyltransferase
- Gene Expression Regulation, Enzymologic
- Geranyltranstransferase
- Hydroxymethylglutaryl CoA Reductases
- Mevalonic Acid
- Oxygenases
- Polyisoprenyl Phosphates
- Protein Processing, Post-Translational