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Article

Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection.

Virology - 5 Feb 2012

Li Hui, Atkins Elizabeth, Bruckner Joseph, McArdle Susan, Qiu Wan Chong, Thomassen Lisa V, Scott John, Shuhart Margaret C, Livingston Stephen, Townshend-Bulson Lisa, McMahon Brian J, Harris Mark, Griffin Stephen, Gretch David R

Abstract excerpt

The present study describes natural genetic heterogeneity of hepatitis C virus (HCV) p7 protein, the ion channel that plays a critical role in assembly and release of HCV, within 299 variants isolated from serum specimens of 27 chronically infected patients, 12 of whom with human immunodeficiency virus (HIV) co-infection. Liver fibrosis stage was inversely correlated with p7 synonymous substitutions (dS)...

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Identifiers

PMID: 22172518
DOI: 10.1016/j.virol.2011.11.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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