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Article

Severe developmental defects in Dictyostelium null mutants for actin-binding proteins.

Mechanisms of development - 1 Mar 2000

Ponte E, Rivero F, Fechheimer M, Noegel A, Bozzaro S

Abstract excerpt

The actin cytoskeleton is implicated in many cellular processes, such as cell adhesion, locomotion, contraction and cytokinesis, which are central to any development. The extent of polymerization, cross-linking, and bundling of actin is regulated by several actin-binding proteins. Knock-out mutations in these proteins have revealed in many cases only subtle, if any, defects in development, suggesting that the...

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PMID: 10704840
DOI: 10.1016/s0925-4773(99)00292-0

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