Article
A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis.
Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2016
Junemann Alexander, Filić Vedrana, Winterhoff Moritz, Nordholz Benjamin, Litschko Christof, Schwellenbach Helena, Stephan Till, Weber Igor, Faix Jan
Abstract excerpt
Phagocytosis and macropinocytosis are Ras-regulated and actin-driven processes that depend on the dynamic rearrangements of the plasma membrane that protrudes and internalizes extracellular material by cup-shaped structures. However, the regulatory mechanisms underlying actin assembly in large-scale endocytosis remain elusive. Here, we show that the Diaphanous-related formin G (ForG) from the professional...
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