Article
An unconventional myosin required for cell polarization and chemotaxis.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Breshears Laura M, Wessels Deborah, Soll David R, Titus Margaret A
Abstract excerpt
MyTH/FERM (myosin tail homology 4/band 4.1, ezrin, radixin, and moesin) myosins have roles in cellular adhesion, extension of actin-filled projections such as filopodia and stereocilia, and directional migration. The amoeba Dictyostelium discoideum expresses a simple complement of MyTH/FERM myosins, a class VII (M7) myosin required for cell-substrate adhesion and a unique myosin named MyoG. Mutants lacking MyoG...
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