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Article

Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review.

American journal of epidemiology - 1 May 2000

Ashley-Koch A, Yang Q, Olney R S

Abstract excerpt

Sickle cell disease is caused by a variant of the beta-globin gene called sickle hemoglobin (Hb S). Inherited autosomal recessively, either two copies of Hb S or one copy of Hb S plus another beta-globin variant (such as Hb C) are required for disease expression. Hb S carriers are protected from malaria infection, and this protection probably led to the high frequency of Hb S in individuals of African and...

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Identifiers

PMID: 10791557
DOI: 10.1093/oxfordjournals.aje.a010288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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