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Article

Differences in the clinical and genotypic presentation of sickle cell disease around the world.

Paediatric respiratory reviews - 1 Mar 2014

Saraf Santosh L, Molokie Robert E, Nouraie Mehdi, Sable Craig A, Luchtman-Jones Lori, Ensing Gregory J, Campbell Andrew D, Rana Sohail R, Niu Xiao M, Machado Roberto F, Gladwin Mark T, Gordeuk Victor R

Abstract excerpt

Sickle cell disease (SCD), caused by a mutation in the β-globin gene HBB, is widely distributed in malaria endemic regions. Cardiopulmonary complications are major causes of morbidity and mortality. Hemoglobin SS (Hb SS) represents a large proportion of SCD in the Americas, United Kingdom, and certain regions of Africa while higher proportions of hemoglobin SC are observed in Burkina Faso and hemoglobin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24361300
DOI: 10.1016/j.prrv.2013.11.003
PMCID: PMC3944316

Genes

SCD
HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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