Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC).

doi:10.1371/journal.pone.0228399

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Article

Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC).

PloS one - 1 Jan 2020

da Guarda Caroline Conceição, Yahouédéhou Sètondji Cocou Modeste Alexandre, Santiago Rayra Pereira, Neres Joelma Santana Dos Santos, Fernandes Camila Felix de Lima, Aleluia Milena Magalhães, Figueiredo Camylla Vilas Boas, Fiuza Luciana Magalhães, Carvalho Suellen Pinheiro, Oliveira Rodrigo Mota de, Fonseca Cleverson Alves, Ndidi Uche Samuel, Nascimento Valma Maria Lopes, Rocha Larissa Carneiro, Goncalves Marilda Souza

Abstract excerpt

Sickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals present highly variable clinical manifestations. Sickle cell anemia (SCA) is the most severe form, while SC hemoglobinopathy (HbSC) is thought to be milder. Thus, we investigated the clinical manifestations and laboratory parameters by comparing each SCD genotype. We designed a cross-sectional study including 126 SCA...

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PMID: 31995624
DOI: 10.1371/journal.pone.0228399
PMCID: PMC6988974

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